path analysis model between spiritual health, quality of life with depression thalasemia major patients

objective: the aim of this study was to investigate relationship between quality of life and spiritual health and depression in thalasemia major patients in amol city.   method: the research method was correlation. the population was 497 of thalasemia patients. according to the cochrane formula 100 thalasemia patients were selected by random sampling method. the research instruments were quality of life questionnaire, spiritual health questionnaire and  depression questionnaire. data were analyzed using pearson correlation, multiple regression and path analysis. results: there is relationship between quality of life and spiritual health and depression. regression analysis showed that quality of life and spiritual health predict thalasemia patients depression. the results of path analysis showed that physical domain quality of life, religious health and existential health through mental domain quality of life indirect effect on depression affects thalasemia patients but mental domain quality of life directly affects the impact on thalasemia patients depression. conclusion: according to the results quality of life, depression and spiritual well-being of patients with thalassemia can be scheduled to take appropriate measures to prevent depression and improve quality of life and lead to spiritual health.